Ipamorelin + CJC-1295 (No DAC) Stack Guide

The Ipamorelin + CJC-1295 (no DAC) stack is the most popular peptide combination in the GH-secretagogue space. This guide covers what each compound does, why they're stacked, dosing, timing, and what to expect.

What each compound does

Ipamorelin (the GHRP)

Ipamorelin is a Growth Hormone Releasing Peptide (GHRP). It binds the ghrelin receptor and triggers a pulse of GH from the pituitary. It's selective — minimal cortisol or prolactin spike compared to older GHRPs (GHRP-2, GHRP-6, hexarelin).

CJC-1295 no DAC (the GHRH analogue)

CJC-1295 (no DAC, sometimes called Mod GRF 1-29) is a GH Releasing Hormone analogue. It potentiates the GH pulse triggered by Ipamorelin — bigger amplitude, more total GH released. The 'no DAC' version has a short half-life (~30 min), preserving the natural pulsatile pattern of GH release.

Why stack them

Synergy. Ipamorelin alone gives a moderate GH pulse. CJC alone gives a stronger pulse but only when natural GH release is also happening. Together, they create a much stronger and cleaner pulse than either alone — typically 5-10× the GH release of either compound used in isolation.

Standard dosing

• Ipamorelin: 200-300 mcg per injection
• CJC-1295 (no DAC): 100-200 mcg per injection
• Frequency: 2× daily (morning fasted + before bed) — some users do 3× daily
• Cycle length: 8-16 weeks, then 4-8 week break

You can mix both peptides in the same syringe and inject SubQ in one shot.

Timing matters

GH pulses are inhibited by elevated blood glucose and elevated free fatty acids. For maximum effect:

• Inject fasted — at least 2 hours since your last meal
• Wait 20-30 min after injection before eating
• Best windows: Morning before breakfast, or 2-3 hours after dinner before bed
• Pre-bed shot stacks with the natural GH pulse during deep sleep

Reconstitution

Both peptides ship as 5 mg vials typically. Common reconstitution:

• Ipamorelin 5mg + 2.5 ml BAC water = 200 mcg per 10 units
• CJC-1295 2mg + 2 ml BAC water = 100 mcg per 10 units

Use the recon calculator to confirm.

What to expect

• Week 1-2: Improved sleep depth, more vivid dreams (GH pulse during deep sleep)
• Week 3-4: Better recovery between sessions, slight skin quality improvement
• Week 6-8: Subtle body composition changes — less visceral fat, more lean tissue if training and nutrition are dialled
• Week 12+: Plateaus tend to hit — that's why most users cycle

Don't expect AAS-level effects. GH peptides are subtle. The wins are mostly recovery, sleep, and body composition over time. They're tools, not magic.

Side effects

Generally well tolerated. Most common: temporary water retention, head rush after injection (CJC dilates blood vessels briefly), tingling or numbness at the injection site. Long-term GH elevation can theoretically affect glucose metabolism — monitor fasting glucose and HbA1c if running for extended cycles.